malignant pleural | mesothelioma treatment
Malignant pleural mesothelioma is a type of cancer that affects the lining of the lungs (pleura) and is primarily caused by exposure to asbestos fibers. The treatment for malignant pleural mesothelioma typically involves a multidisciplinary approach and may include various options depending on the stage of the disease and the overall health of the patient. Here are some common treatment options for malignant pleural mesothelioma:1. Surgery: Surgical interventions aim to remove as much of the tumor as possible. Procedures such as pleurectomy/decortication (P/D) involve removing the affected pleural lining and potentially other affected tissues, while extrapleural pneumonectomy (EPP) involves removing the pleura, lung, and other affected structures. Surgery may be followed by other treatments.2. Chemotherapy: Chemotherapy involves the use of powerful drugs to kill cancer cells or slow their growth. It can be administered intravenously or directly into the chest cavity (intracavitary chemotherapy). Chemotherapy is often used as a neoadjuvant treatment before surgery or as an adjuvant treatment after surgery.3. Radiation therapy: Radiation therapy uses high-energy X-rays or other radiation sources to target and destroy cancer cells. It can be delivered externally (external beam radiation therapy) or internally through implanted radioactive substances (brachytherapy). Radiation therapy may be used before or after surgery or as palliative treatment to relieve symptoms.4. Immunotherapy: Immunotherapy treatments aim to enhance the body’s immune system to recognize and attack cancer cells. Immune checkpoint inhibitors, such as pembrolizumab or nivolumab, have shown promise in treating certain cases of malignant pleural mesothelioma.5. Targeted therapy: Targeted therapy utilizes drugs that specifically target genetic mutations or altered proteins present in cancer cells. However, targeted therapy options for mesothelioma are currently limited, and their use is still being investigated in clinical trials.6. Multimodal therapy: This approach combines two or more treatments, such as surgery, chemotherapy, and radiation therapy, to maximize the chances of controlling or eliminating the cancer.7. Palliative care: Palliative care focuses on providing relief from symptoms, improving quality of life, and supporting the overall well-being of patients. It can involve pain management, respiratory support, and addressing emotional and psychological needs.It’s important to note that treatment plans may vary depending on individual factors, including the stage of the disease, overall health, and personal preferences. Consulting with a healthcare team specializing in mesothelioma can provide personalized guidance on the most appropriate treatment options. Additionally, participating in clinical trials may offer access to innovative therapies being developed for malignant pleural mesothelioma.